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Infinity Holistic Healthcare

Chapel Hill, NC 27514

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Histamine Intolerance and MCAS

Does it feel like your immune system is bonkers?

Does it feel like your body is becoming less and less tolerant of foods,

   allergens, and the world in general?

Are you frustrated with your medical team and their lack of solutions?

Hi, I'm Dr. DiNezza.

Over the last ten years I have had the privilege of helping many people with allergies, histamine intolerance, mast cell disease, and everything in between. I would be honored to help you on your healing journey- please have a look around and don't hesitate to reach out if you have any questions.

But Don't Take It From Me!

Below are just a few reviews from folks with histamine intolerance whom I have helped.


Want to hear more of what my patients have to say? Click here for more testimonials.

About Histamine Intolerance and MCAS

Histamine intolerance and Mast Cell Activation Syndrome/Disorder are inflammatory, allergic conditions that predominantly affect one type of immune cell (mast cells). Oftentimes, people with MCAS get ping-ponged from doctor to doctor without proper treatment or help. While managing these conditions take a lot of time, patience, and effort, there is much that can be done to calm that inflammation.

What are the symptoms of Histamine Intolerance?

Common symptoms of histamine intolerance include:

  • Diarrhea

  • Irritable Bowel Syndrome

  • Migraines/Headaches

  • Hives

  • Eczema

  • Particularly bad seasonal allergies

  • Dizziness or vertigo

  • Arrhythmia

  • Anxiety

  • POTS

  • Daytime sleepiness

  • Fatigue

You may have all of these symptoms or only a few.

What are the causes of Histamine Intolerance?

That's the million dollar question!

Hypothesized causes of histamine intolerance include:

  • Small Intestinal Bacterial Overgrowth (SIBO)

  • Dysbiosis (imbalanced gut bugs)

  • Drug or toxin exposure

  • Stress

  • Viral infections

  • Genetic SNPs

It is not uncommon for people to have more than one trigger.

Can a diet control histamine intolerance?

Yes! Decreasing dietary histamine goes a long way in treating your symptoms. How much histamine you can tolerate often is a reflection of how well you're managing other things (sleep, stress) and can change over time. It is always my goal to help patients so that they can tolerate more histmaine (from food) over time.

Diets that can help MCAS and HI (and that I have worked with) include:

  • Low histamine diet

Can histamine intolerance and MCAS be helped naturally or cured?

Like autoimmune diseases, MCAS can be put into remission but (to my knowledge) cannot be cured. However, there is tremendous value (and symptomatic change) to be had from calming/inhibiting mast cells, preventing secondary issues, and decreasing inflammation.


Both conditions often times responds very well to dietary changes, herbal medicine, supplements, vitamins, and life coaching. Although it takes a lot of hard work and dedication, there is a lot that can be done for these conditions.

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